Article
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Nature immunology - 1 Aug 2009
Johnson Andy L, Aravind L, Shulzhenko Natalia, Morgun Andre, Choi See-Young, Crockford Tanya L, Lambe Teresa, Domaschenz Heather, Kucharska Edyta M, Zheng Lixin, Vinuesa Carola G, Lenardo Michael J, Goodnow Christopher C, Cornall Richard J, Schwartz Ronald H
Abstract excerpt
T cell antigen receptor (TCR) signaling in CD4(+)CD8(+) double-positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a previously unknown T lineage-specific gene, Themis, which is critical for the completion of positive selection. Themis contains a tandem...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.