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Article

Evidence for evolutionary conservation of sex-determining genes.

Nature - 12 Feb 1998

Raymond C S, Shamu C E, Shen M M, Seifert K J, Hirsch B, Hodgkin J, Zarkower D

Abstract excerpt

Most metazoans occur as two sexes. Surprisingly, molecular analyses have hitherto indicated that sex-determining mechanisms differ completely between phyla. Here we present evidence to the contrary. We have isolated the male sexual regulatory gene mab-3 from the nematode Caenorhabditis elegans and found that it is related to the Drosophila melanogaster sexual regulatory gene doublesex (dsx)2. Both genes encode...

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PMID: 9490411
DOI: 10.1038/35618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Evidence for evolutionary conservation of sex-determining genes.PMID 9490411Read ↗

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A panoramic view of the expression and function of the Doublesex/DMRT gene family in <i>C. elegans</i>Semantic proximity Read ↗

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Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family.Semantic proximity Read ↗

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