Evidence for evolutionary conservation of sex-determining genes.

doi:10.1038/35618

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Article

Evidence for evolutionary conservation of sex-determining genes.

Nature - 12 Feb 1998

Raymond C S, Shamu C E, Shen M M, Seifert K J, Hirsch B, Hodgkin J, Zarkower D

Abstract excerpt

Most metazoans occur as two sexes. Surprisingly, molecular analyses have hitherto indicated that sex-determining mechanisms differ completely between phyla. Here we present evidence to the contrary. We have isolated the male sexual regulatory gene mab-3 from the nematode Caenorhabditis elegans an...

Topics

Adaptor Proteins, Signal Transducing
Alternative Splicing
Amino Acid Sequence
Animals
Biological Evolution
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Chromosome Mapping
Chromosomes, Human, Pair 9
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Female
Helminth Proteins
Humans
Insect Proteins
Male
Membrane Proteins

Source

Open in PubMed

Identifiers

PMID: 9490411
DOI: 10.1038/35618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9490411-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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