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Article

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.

Genes & development - 15 Jul 2017

Simón-Carrasco Lucía, Graña Osvaldo, Salmón Marina, Jacob Harrys K C, Gutierrez Alejandro, Jiménez Gerardo, Drosten Matthias, Barbacid Mariano

Abstract excerpt

CIC (also known as Capicua) is a transcriptional repressor negatively regulated by RAS/MAPK signaling. Whereas the functions of Cic have been well characterized in Drosophila, little is known about its role in mammals. CIC is inactivated in a variety of human tumors and has been implicated recently in the promotion of lung metastases. Here, we describe a mouse model in which we inactivated Cic by selectively...

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Source

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Identifiers

PMID: 28827401
DOI: 10.1101/gad.300244.117
PMCID: PMC5588927

Genes

CIC
ETV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.PMID 28827401Read ↗

Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.Semantic proximity Read ↗

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancerSemantic proximity Read ↗

Comparative transcriptome analysis of isogenic cell line models and primary cancers links capicua ( CIC ) loss to activation of the MAPK signalling cascadeSemantic proximity Read ↗

Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse modelsSemantic proximity Read ↗

Expression of the CIC-DUX4 fusion oncoprotein mimics human CIC-rearranged sarcoma in genetically engineered mouse modelsSemantic proximity Read ↗

Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice.Semantic proximity Read ↗

Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factorsSemantic proximity Read ↗

The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations.Semantic proximity Read ↗

Multi-omic analysis of CIC’s functional networks reveals novel interaction partners and a potential role in mitotic fidelitySemantic proximity Read ↗

Incomplete developmental silencing of cancer-testis antigen BORIS in humanized mouse model promotes cancer susceptibilitySemantic proximity Read ↗

ERK inhibits Cic repressor function via multisite phosphorylationSemantic proximity Read ↗

The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progressionSemantic proximity Read ↗

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