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Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

23 Nov 2020

Abstract excerpt

Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific antigens (TSAs). Recent work has shown that gene-expression patterns within the mTEC compartment are heterogenous and include multiple differentiated cell states. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33226342
DOI: 10.7554/elife.60188

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