Heart development in normal and cardiac-lethal mutant axolotls: a model for the control of vertebrate cardiogenesis.

doi:10.1111/j.1432-0436.1991.tb00230.x

Back to search

Article

Heart development in normal and cardiac-lethal mutant axolotls: a model for the control of vertebrate cardiogenesis.

Differentiation; research in biological diversity - 1 Aug 1991

Smith S C, Armstrong J B

Abstract excerpt

The mechanisms which regulate myocardial differentiation are poorly understood. The cardiac-lethal (c) mutant of Ambystoma mexicanum, in which the heart never begins to beat, provides a valuable model system for studying this process. Using an in vitro assay, we examine the nature of the defect i...

Topics

Ambystoma mexicanum
Animals
Culture Techniques
Endoderm
Genes, Lethal
Heart
Mesoderm
Models, Cardiovascular
Mutation
Reference Values
Vertebrates

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.