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Article

Activin A and transforming growth factor-beta stimulate heart formation in axolotls but not rescue cardiac lethal mutants.

Cell and tissue research - 1 Nov 1995

Mangiacapra F J, Fransen M E, Lemanski L F

Abstract excerpt

In the Mexican axolotl (salamander), Ambystoma mexicanum, a recessive cardiac lethal mutation causes an incomplete differentiation of the myocardium. Mutant hearts lack organized sarcomeric myofibrils and do not contract throughout their lengths. We have previously shown that RNA purified from normal anterior endoderm or from juvenile heart tissue is able to rescue mutant embryonic hearts in an in vitro organ...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8565053
DOI: 10.1007/BF00319114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activin A and transforming growth factor-beta stimulate heart formation in axolotls but not rescue cardiac lethal mutants.PMID 8565053Read ↗

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A new unique form of microRNA from human heart, microRNA-499c, promotes myofibril formation and rescues cardiac development in mutant axolotl embryos.Semantic proximity Read ↗

Confocal microscopy of a newly identified protein associated with heart development in the Mexican axolotl.Semantic proximity Read ↗

A novel protein involved in heart development in Ambystoma mexicanum is localized in endoplasmic reticulum.Semantic proximity Read ↗

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Characterization of a TM-4 type tropomyosin that is essential for myofibrillogenesis and contractile activity in embryonic hearts of the Mexican axolotl.Semantic proximity Read ↗

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