Reaction-diffusion control of heart development: evidence for activation and inhibition in precardiac mesoderm.

Abstract excerpt

In axolotl embryos homozygous for the cardiac-lethal (c) gene, the heart never begins to beat. Recently, we demonstrated that the c gene affects the heart mesoderm directly, making the latter incapable of responding to normal inductive stimuli. Based on these results, we proposed that a reaction-diffusion mechanism controls the later stages of vertebrate cardiogenesis. In the present study, we use a series of...

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