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Article

Tssk6 is required for Izumo relocalization and gamete fusion in the mouse

14 Jul 2009

Abstract excerpt

One of the most important processes in fertilization is the fusion of egg and sperm; however, the molecular mechanisms involved in this process are not well understood. So far, using genetic approaches, only two proteins have been demonstrated to be necessary for this process: Izumo in sperm and CD9 in the egg. Here we demonstrate that sperm produced by Tssk6 (Sstk)-null mice present defects that prevent the...

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PMID: 19596796
DOI: 10.1242/jcs.047225

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