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Article

Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion

24 Mar 2020

Abstract excerpt

Three genes are known to be essential for gamete adhesion/fusion (Cd9, Izumo1 and Juno). Here, we confirmed that Spaca6 null males are infertile and showed that their sperm accumulate in the perivitelline space but are unable to fuse with oocyte. Like IZUMO1, SPACA6 which is expressed by human sperm, is remained on the equatorial segment after acrosomal reaction and is involved in human fertilization since an...

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PMID: 32210282
DOI: 10.1038/s41598-020-62091-y

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