Article
Transcription factor AP-2beta inhibits glucose-induced insulin secretion in cultured insulin-secreting cell-line.
Diabetes research and clinical practice - 1 Sept 2009
Tsukada Shuichi, Kobayashi Masa-Aki, Omori Shintaro, Unoki Hiroyuki, Maeda Shiro
Abstract excerpt
AIM: We previously identified the transcription factor activating enhancer-binding protein-2beta (AP-2beta) gene as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of AP-2beta in the pathogenesis of type 2 diabetes we examined the effects of AP-2beta on glucose-induced insulin secretion. METHODS: We measured the insulin secretion stimulated by glucose,...
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