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Article

Drosophila ia2 modulates secretion of insulin-like peptide.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology - 1 Oct 2008

Kim Jihyun, Bang Hyojoo, Ko Syungkyun, Jung Inhee, Hong Haehee, Kim-Ha Jeongsil

Abstract excerpt

Islet antigen-2 (IA-2) is a major autoantigen in type I diabetes. To throw light on the function of IA-2 we examined the role of ia2, a Drosophila homologue, during Drosophila development. In situ hybridization showed that ia2 was expressed in the central nervous system and midgut region. The neuronal expression pattern of ia2 was very similar to that of IA-2 in mammals. Disruption of gut-specific ia2 expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18634898
DOI: 10.1016/j.cbpa.2008.06.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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