Article
Regulation of insulin secretion by overexpression of Ca2+/calmodulin-dependent protein kinase II in insulinoma MIN6 cells.
Endocrinology - 1 Jul 2000
Tabuchi H, Yamamoto H, Matsumoto K, Ebihara K, Takeuchi Y, Fukunaga K, Hiraoka H, Sasaki Y, Shichiri M, Miyamoto E
Abstract excerpt
Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) may play a key role in Ca2+-induced insulin secretion. We have previously reported that treatment of insulinoma MIN6 cells with secretagogues activated CaM kinase II and increased the phosphorylation of synapsin I, followed by insulin secretion. Here, we identified isoforms of CaM kinase II in MIN6 cells and rat islets. Immunoblot analysis suggested that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.