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Article

Mutational analysis of human T-cell leukemia virus type 2 Tax.

Journal of virology - 1 Nov 1997

Ross T M, Minella A C, Fang Z Y, Pettiford S M, Green P L

Abstract excerpt

A mutational analysis of human T-cell leukemia virus type 2 (HTLV-2) Tax (Tax-2) was performed to identify regions within Tax-2 important for activation of promoters through the CREB/ATF or NF-kappaB/Rel signaling pathway. Tax-2 mutations within the putative zinc-binding region as well as mutations at the carboxy terminus disrupted CREB/ATF transactivation. A single mutation within the central proline-rich region...

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Identifiers

PMID: 9343258
DOI: 10.1128/JVI.71.11.8912-8917.1997
PMCID: PMC192364

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