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Article

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.

Oncogene - 19 Apr 2001

Iwanaga R, Ohtani K, Hayashi T, Nakamura M

Abstract excerpt

The trans-activator protein Tax of human T-cell leukemia virus type I (HTLV-I) plays an important role in the development of adult T-cell leukemia through, at least in part, its ability to stimulate cell growth. We previously reported that Tax induced cell cycle progression from G0/G1 phase to S and G2/M phases in human T-cell line Kit 225 cells. To elucidate molecular mechanism of Tax-induced cell cycle...

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Identifiers

PMID: 11360190
DOI: 10.1038/sj.onc.1204304

Genes

CDK2
CDK4
CDK6
E2F1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.PMID 11360190Read ↗

Molecular mechanisms of cellular transformation by HTLV-1 Tax.Semantic proximity Read ↗

Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells.Semantic proximity Read ↗

Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional DifferencesSemantic proximity Read ↗

Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors.Semantic proximity Read ↗

IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1.Semantic proximity Read ↗

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.Semantic proximity Read ↗

Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I–transformed cellsSemantic proximity Read ↗

Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma.Semantic proximity Read ↗

Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Semantic proximity Read ↗

Central role of PI3K in transcriptional activation of hTERT in HTLV-I–infected cellsSemantic proximity Read ↗

P53 facilitates degradation of human T-cell leukaemia virus type I Tax-binding protein through a proteasome-dependent pathway.Semantic proximity Read ↗

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.Semantic proximity Read ↗

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