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Article

Transdominant human T-cell lymphotropic virus type I TAX1 mutant that fails to localize to the nucleus.

Journal of virology - 1 May 1991

Gitlin S D, Lindholm P F, Marriott S J, Brady J N

Abstract excerpt

Human T-cell lymphotropic virus type I (HTLV-I) encodes a 40-kDa nuclear transactivating phosphoprotein, TAX1. The results presented in this study demonstrate that deletion of amino acids 2 through 59 of TAX1 (delta 58 TAX1) decreased transactivation of the HTLV-I long terminal repeat 10- to 20-fold. S1 nuclease analysis revealed that the decrease in transactivation of the HTLV-I long terminal repeat was...

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Identifiers

PMID: 2016773
DOI: 10.1128/JVI.65.5.2612-2621.1991
PMCID: PMC240619

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Source receipt: pubmed, retrieved 7 Sept 2026.

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