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Article

Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8.

Scientific reports - 16 Oct 2017

Kim Hyun-Taek, Lee Mi-Sun, Jeong Yun-Mi, Ro Hyunju, Kim Dong-Il, Shin Yong-Hwan, Kim Ji-Eun, Hwang Kyu-Seok, Choi Jung-Hwa, Bahn Minjin, Lee Jeong-Ju, Lee Sang H, Bae Young-Ki, Lee Jin-Soo, Choi Joong-Kook, Kim Nam-Soon, Yeo Chang-Yeol, Kim Cheol-Hee

Abstract excerpt

Wnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of a novel regulator of Wnt signaling, OTTOGI (OTG), isolated from a large-scale expression screening of human cDNAs in zebrafish embryos. Overexpression of OTG in zebrafish embryos caused dorso-anteriorized phenotype, inhibited the expression of Wnt target genes, and prevented nuclear...

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Identifiers

PMID: 29038508
DOI: 10.1038/s41598-017-13429-6
PMCID: PMC5643531

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