Article
ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009
Zong Yang, Xin Li, Goldstein Andrew S, Lawson Devon A, Teitell Michael A, Witte Owen N
Abstract excerpt
Chromosomal rearrangements involving erythroblast transformation specific (ETS) family transcription factors were recently defined as the most common genetic alterations in human prostate cancer. Despite their prevalence, it is unclear what quantitative role they play in either initiation or progression of the disease. Using a lentiviral transduction and dissociated cell prostate regeneration approach, we find...
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