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Article

A causal role for ERG in neoplastic transformation of prostate epithelium

1 Feb 2008

Abstract excerpt

A significant proportion of human prostate cancers carry a chromosomal rearrangement resulting in the overexpression of the ETS transcription factor, ERG; however, the functional significance of this event is poorly understood. We report here that up-regulation of ERG transcript is sufficient for the initiation of prostate neoplasia. In agreement with measurements of ERG transcripts, we found that ERG protein is...

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PMID: 18245377
DOI: 10.1073/pnas.0711711105

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A causal role for ERG in neoplastic transformation of prostate epitheliumPMID 18245377Read ↗

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Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.Semantic proximity Read ↗

Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia ( PIN ) and intraductal carcinoma through retrograde glandular colonizationSemantic proximity Read ↗

ERG orchestrates chromatin interactions to drive prostate cell fate reprogrammingSemantic proximity Read ↗

ETS fusion genes in prostate cancerSemantic proximity Read ↗

Transcriptional network involving ERG and AR orchestrates Distal-Less Homeobox 1 mediated prostate cancer progressionSemantic proximity Read ↗

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ERG orchestrates chromatin interactions to drive prostate cell fate reprogrammingSemantic proximity Read ↗

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.Semantic proximity Read ↗

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