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Article

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.

Nature medicine - 1 Aug 2013

Chen Yu, Chi Ping, Rockowitz Shira, Iaquinta Phillip J, Shamu Tambudzai, Shukla Shipra, Gao Dong, Sirota Inna, Carver Brett S, Wongvipat John, Scher Howard I, Zheng Deyou, Sawyers Charles L

Abstract excerpt

Studies of ETS-mediated prostate oncogenesis have been hampered by a lack of suitable experimental systems. Here we describe a new conditional mouse model that shows robust, homogenous ERG expression throughout the prostate. When combined with homozygous Pten loss, the mice developed accelerated, highly penetrant invasive prostate cancer. In mouse prostate tissue, ERG markedly increased androgen receptor (AR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23817021
DOI: 10.1038/nm.3216
PMCID: PMC3737318

Genes

ERG
PTEN
ETV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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