Article
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis.
Nature - 29 Jun 2017
Bose Rohit, Karthaus Wouter R, Armenia Joshua, Abida Wassim, Iaquinta Phillip J, Zhang Zeda, Wongvipat John, Wasmuth Elizabeth V, Shah Neel, Sullivan Patrick S, Doran Michael G, Wang Ping, Patruno Anna, Zhao Yilin, Zheng Deyou, Schultz Nikolaus, Sawyers Charles L
Abstract excerpt
Half of all prostate cancers are caused by the TMPRSS2-ERG gene-fusion, which enables androgens to drive expression of the normally silent E26 transformation-specific (ETS) transcription factor ERG in prostate cells. Recent genomic landscape studies of such cancers have reported recurrent point mutations and focal deletions of another ETS member, the ETS2 repressor factor ERF. Here we show these ERF mutations...
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