Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERG-Mediated Coregulator Complex Formation Maintains Androgen Receptor Signaling in Prostate Cancer

15 Sept 2020

Abstract excerpt

Abstract The TMPRSS2-ERG fusion is the most common genomic rearrangement in human prostate cancer. However, in established adenocarcinoma, it is unknown how the ERG oncogene promotes a cancerous phenotype and maintains downstream androgen receptor (AR) signaling pathways. In this study, we utilized a murine prostate organoid system to explore the effects of ERG on tumorigenesis and determined the mechanism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Estrogen and related hormone effects
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32934023
DOI: 10.1158/0008-5472.can-20-2044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERG-Mediated Coregulator Complex Formation Maintains Androgen Receptor Signaling in Prostate CancerPMID 32934023Read ↗

SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG.Semantic proximity Read ↗

Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancerSemantic proximity Read ↗

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.Semantic proximity Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradationSemantic proximity Read ↗

ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratificationSemantic proximity Read ↗

Common Gene Rearrangements in Prostate CancerSemantic proximity Read ↗

Oncogenic activation of <i>ERG:</i> A predominant mechanism in prostate cancerSemantic proximity Read ↗

ERG orchestrates chromatin interactions to drive prostate cell fate reprogrammingSemantic proximity Read ↗

ERG orchestrates chromatin interactions to drive prostate cell fate reprogrammingSemantic proximity Read ↗

ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells.Semantic proximity Read ↗

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.