Article

Transcriptional network involving ERG and AR orchestrates Distal-Less Homeobox 1 mediated prostate cancer progression

2020-10-23

Abstract excerpt

<title>Abstract</title> <p>Nearly half of the prostate cancer (PCa) cases show elevated levels of ERG oncoprotein due to TMPRSS2-ERG gene fusion. Here, we demonstrate ERG mediated upregulation of Distal-less homeobox-1 (DLX1), an established PCa biomarker. Using series of functional assays, we show DLX1 elicits oncogenic properties in prostate epithelial cells, and abrogating its function leads to reduced tumor b...

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Identifiers and source

Literature Corpus work: 27143052-7095-551a-9694-0fe83e60660e
DOI: 10.21203/rs.3.rs-88679/v1

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