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Article

Misclassification of drug failure in Plasmodium falciparum clinical trials in southeast Asia.

The Journal of infectious diseases - 15 Aug 2009

Juliano Jonathan J, Ariey Frederic, Sem Rithy, Tangpukdee Noppadon, Krudsood Srivicha, Olson Carol, Looareesuwan Sornchai, Rogers William O, Wongsrichanalai Chansuda, Meshnick Steven R

Abstract excerpt

Most trials of antimalarials occur in areas in which reinfections are possible. For Plasmodium falciparum, reinfections are distinguished from recrudescences by polymerase chain reaction analysis of 3 polymorphic genes. However, the validity of this approach has never been rigorously tested. We tested for misclassification in 6 patients from clinical trials in Thailand and Cambodia who were classified as being...

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Identifiers

PMID: 19591576
DOI: 10.1086/600892
PMCID: PMC2761972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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