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Article

Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials.

Antimicrobial agents and chemotherapy - 1 Sept 2007

Greenhouse Bryan, Dokomajilar Christian, Hubbard Alan, Rosenthal Philip J, Dorsey Grant

Abstract excerpt

Antimalarial clinical trials use genotyping techniques to distinguish new infection from recrudescence. In areas of high transmission, the accuracy of genotyping may be compromised due to the high number of infecting parasite strains. We compared the accuracies of genotyping methods, using up to six genotyping markers, to assign outcomes for two large antimalarial trials performed in areas of Africa with...

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Identifiers

PMID: 17591848
DOI: 10.1128/AAC.00159-07
PMCID: PMC2043236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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