Article
Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp.
The American journal of tropical medicine and hygiene - 1 Feb 2003
Cattamanchi Adithya, Kyabayinze Daniel, Hubbard Alan, Rosenthal Philip J, Dorsey Grant
Abstract excerpt
Genotyping frequently is used to distinguish recrudescent from new infections in antimalarial drug efficacy trials, but methodology and interpretation of results have not been standardized. We compared the utility of polymorphisms within 3 Plasmodium falciparum genes during a longitudinal trial i...
Topics
- Amodiaquine
- Animals
- Antigens, Protozoan
- Antimalarials
- Artemisinins
- Artesunate
- Child, Preschool
- DNA, Protozoan
- Drug Combinations
- Drug Resistance
- Female
- Genotype
- Humans
- Infant
- Longitudinal Studies
- Malaria, Falciparum
- Male
- Merozoite Surface Protein 1