Article
Natural Products and the Gene Cluster Revolution.
Trends in microbiology - 1 Dec 2016
Jensen Paul R
Abstract excerpt
Genome sequencing has created unprecedented opportunities for natural-product discovery and new insight into the diversity and distributions of natural-product biosynthetic gene clusters (BGCs). These gene collectives are highly evolved for horizontal exchange, thus providing immediate opportunities to test the effects of small molecules on fitness. The marine actinomycete genus Salinispora maintains...
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