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Article

Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling.

The Journal of biological chemistry - 29 Oct 2010

Kale Andrew J, McGlinchey Ryan P, Moore Bradley S

Abstract excerpt

SalM is a short-chain dehydrogenase/reductase enzyme from the marine actinomycete Salinispora tropica that is involved in the biosynthesis of chloroethylmalonyl-CoA, a novel halogenated polyketide synthase extender unit of the proteasome inhibitor salinosporamide A. SalM was heterologously overexpressed in Escherichia coli and characterized in vitro for its substrate specificity, kinetics, and reaction profile. A...

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Identifiers

PMID: 20736169
DOI: 10.1074/jbc.M110.153833
PMCID: PMC2962469

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