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Mining the Cinnabaramide Biosynthetic Pathway to Generate Novel Proteasome Inhibitors

8 Mar 2011

Abstract excerpt

The cinnabaramides and salinosporamides are mixed PKS/NRPS natural products isolated from a terrestrial streptomycete and a marine actinomycete, respectively. They interfere with the proteasome and thus potentially inhibit the growth of cancer cells. The compounds exhibit a γ-lactam-β-lactone bicyclic ring structure attached to a cyclohexenyl unit and a PKS side chain. As a first step towards improving anticancer...

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PMID: 21387511
DOI: 10.1002/cbic.201100024

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