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Article

Two of a Kind--The Biosynthetic Pathways of Chlorotonil and Anthracimycin.

ACS chemical biology - 20 Nov 2015

Jungmann Katrin, Jansen Rolf, Gerth Klaus, Huch Volker, Krug Daniel, Fenical William, Müller Rolf

Abstract excerpt

Chlorotonil A is a novel polyketide isolated from the myxobacterium Sorangium cellulosum So ce1525 that features a unique gem-dichloro-1,3-dione moiety. It exhibits potent bioactivity, most notably against the problematic malaria pathogen Plasmodium falciparum in the nanomolar range. In addition, strong antibacterial and moderate antifungal activity were determined. The outstanding biological activity of...

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PMID: 26348978
DOI: 10.1021/acschembio.5b00523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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