Article
Subtypes of familial breast tumours revealed by expression and copy number profiling.
Breast cancer research and treatment - 1 Oct 2010
Waddell Nic, Arnold Jeremy, Cocciardi Sibylle, da Silva Leonard, Marsh Anna, Riley Joan, Johnstone Cameron N, Orloff Mohammed, Assie Guillaume, Eng Charis, Reid Lynne, Keith Patricia, Yan Max, Fox Stephen, Devilee Peter, Godwin Andrew K, Hogervorst Frans B L, Couch Fergus, Grimmond Sean, Flanagan James M, Khanna Kumkum, Simpson Peter T, Lakhani Sunil R, Chenevix-Trench Georgia
Abstract excerpt
Extensive expression profiling studies have shown that sporadic breast cancer is composed of five clinically relevant molecular subtypes. However, although BRCA1-related tumours are known to be predominantly basal-like, there are few published data on other classes of familial breast tumours. We analysed a cohort of 75 BRCA1, BRCA2 and non-BRCA1/2 breast tumours by gene expression profiling and found that 74%...
Topics
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Chromosome Aberrations
- Cluster Analysis
- Cohort Studies
- Comparative Genomic Hybridization
- DNA Methylation