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Article

Identification of a null allele of cytochrome P450 3A7: CYP3A7 polymorphism in a Korean population.

Molecular biology reports - 1 Jan 2010

Lee Sang Seop, Jung Hyun-Ju, Park Jung Soon, Cha In-June, Cho Doo-Yeoun, Shin Jae-Gook

Abstract excerpt

Cytochrome P450 3A7 (CYP3A7) is expressed in the human fetal liver and plays a role in the metabolism of hormones, drugs, and toxic compounds. Genetic variants of CYP3A7 are associated with serum estrone level, bone density, and hepatic CYP3A activity in adults. We analyzed the genetic variations of CYP3A7 in a Korean population. From direct sequencing of all exons and flanking regions of the CYP3A7 gene in 48...

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PMID: 19585271
DOI: 10.1007/s11033-009-9608-1

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