Article
Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.
Therapeutic drug monitoring - 1 Feb 2008
Yea Sung Su, Lee Sang Seop, Kim Woo-Young, Liu Kwang-Hyeon, Kim Hyojin, Shon Ji-Hong, Cha In-June, Shin Jae-Gook
Abstract excerpt
Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important mechanisms for host defense against xenobiotics and endobiotics. Although genetic polymorphisms of several UGT1A isoforms have been reported separately, the haplotypes in all functional exons have not been identified, and little information is available regarding single nucleotide polymorphisms in Koreans. We analyzed...
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