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Article

Complex Splicing and Neural Expression of Duplicated Tau Genes in Zebrafish Embryos

26 Aug 2009

Abstract excerpt

Microtubule-associated protein tau (MAPT) is the major component of the neurofibrillary tangles found in the brains of those suffering from Alzheimer's disease. Various forms of tau lesions are found in other neurodegenerative diseases (tauopathies). We report identification of two MAPT paralogous genes in zebrafish, mapta and maptb, and analysis of their expression patterns during embryonic development. The two...

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PMID: 19584432
DOI: 10.3233/jad-2009-1145

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