Article
Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2009
Hartmann Wolfgang, Küchler Jan, Koch Arend, Friedrichs Nicolaus, Waha Anke, Endl Elmar, Czerwitzki Jacqueline, Metzger Dagmar, Steiner Susanne, Wurst Peter, Leuschner Ivo, von Schweinitz Dietrich, Buettner Reinhard, Pietsch Torsten
Abstract excerpt
PURPOSE: Hepatoblastoma represents the most frequent malignant liver tumor in childhood. The phosphatidylinositol-3'-kinase (PI3K)/AKT pathway is crucial in downstream signaling of multiple receptor tyrosine kinases of pathogenic importance in hepatoblastoma. Increased PI3K/AKT signaling pathway activity and activating mutations of PIK3CA, encoding a PI3K catalytic subunit, have been reported in different...
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