Article
The -383A>C TNFRI polymorphism is associated with soluble levels and clinical activity in rheumatoid arthritis.
Rheumatology international - 1 Mar 2010
Valle Y, Padilla-Gutiérrez J R, Torres-Carrillo N M, Ledezma-Lozano I Y, Corona-Sánchez E G, Vázquez-Del Mercado M, Rangel-Villalobos H, Gámez-Nava J I, González-López L, Muñoz-Valle José Francisco
Abstract excerpt
Tumor necrosis factor-alpha (TNF-alpha) plays a central role in inflammation, and it has been directly implicated in the pathogenesis of rheumatoid arthritis (RA). TNF-alpha activity is mediated through TNFRI and TNFRII cell surface receptors, which act as physiological attenuators of TNF-alpha activity. We recruited 190 RA patients and 190 healthy subjects (HS) in order to associate the -383A>C TNFRI...
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