Article
Genetic determinants of circulating levels of tumor necrosis factor receptor II and their association with TNF-RII gene polymorphisms.
Cytokine - 1 Jul 2010
Vistoropsky Yulia, Ermakov Sergey, Toliat Mohammad Reza, Trofimov Svetlana, Altmüller Janine, Malkin Ida, Nürnberg Peter, Livshits Gregory
Abstract excerpt
BACKGROUND: Tumor necrosis factor alpha (TNFalpha) is a cytokine involved in inflammatory, immune, and metabolic events. TNFalpha signals are mediated through activation of two receptors, one of which is tumor necrosis factor receptor TNF-RII. OBJECTIVE: To examine the effects of genetic and environmental factors on TNF-RII plasma concentration and its association with polymorphisms in the TNF-RII gene locus....
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