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Article

Model structure of APOBEC3C reveals a binding pocket modulating ribonucleic acid interaction required for encapsidation

6 Jul 2009

Abstract excerpt

Human APOBEC3 (A3) proteins form part of the intrinsic immunity to retroviruses. Carrying 1 or 2 copies of a cytidine deaminase motif, A3s act by deamination of retroviral genomes during reverse transcription. HIV-1 overcomes this inhibition by the Vif protein, which prevents incorporation of A3 into virions. In this study we modeled and probed the structure of APOBEC3C (A3C), a single-domain A3 with strong...

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PMID: 19581596
DOI: 10.1073/pnas.0900979106

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Model structure of APOBEC3C reveals a binding pocket modulating ribonucleic acid interaction required for encapsidationPMID 19581596Read ↗

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