Article
Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.
Human molecular genetics - 1 Jul 2011
Nan Hongmei, Xu Mousheng, Zhang Jiangwen, Zhang Mingfeng, Kraft Peter, Qureshi Abrar A, Chen Constance, Guo Qun, Hu Frank B, Rimm Eric B, Curhan Gary, Song Yiqing, Amos Christopher I, Wang Li-E, Lee Jeffrey E, Wei Qingyi, Hunter David J, Han Jiali
Abstract excerpt
We conducted a genome-wide association study on the number of melanocytic nevi reported by 9136 individuals of European ancestry, with follow-up replication in 3581 individuals. We identified the nidogen 1 (NID1) gene on 1q42 associated with nevus count (two linked single nucleotide polymorphisms with r(2) > 0.9: rs3768080 A allele associated with reduced count, P = 6.5 × 10(-8); and rs10754833 T allele...
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