Article
Evaluation of PAX3 genetic variants and nevus number.
Pigment cell & melanoma research - 1 Sept 2013
Ogbah Zighereda, Badenas Celia, Harland Mark, Puig-Butille Joan A, Elliot Fay, Bonifaci Nuria, Guino Elisabet, Randerson-Moor Julie, Chan May, Iles Mark M, Glass Daniel, Brown Andrew A, Carrera Cristina, Kolm Isabel, Bataille Veronique, Spector Timothy D, Malvehy Josep, Newton-Bishop Julia, Pujana Miquel A, Bishop Tim, Puig Susana
Abstract excerpt
The presence of a high nevus number is the strongest phenotypic predictor of melanoma risk. Here, we describe the results of a three-stage study directed at identifying risk variants for the high nevus phenotype. At the first stage, 263 melanoma cases from Barcelona were genotyped for 223 single-nucleotide polymorphisms (SNPs) in 39 candidate genes. Seven SNPs in the PAX3 gene were found to be significantly...
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