Article
Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Familial cancer - 1 Dec 2010
Yang Xiaohong Rose, Liang Xueying, Pfeiffer Ruth M, Wheeler William, Maeder Dennis, Burdette Laurie, Yeager Meredith, Chanock Stephen, Tucker Margaret A, Goldstein Alisa M
Abstract excerpt
Chromosome 9p21 has been implicated in the pathogenesis of cutaneous malignant melanoma (CMM). In addition to CDKN2A, the major known high-risk susceptibility gene for CMM, recent studies suggest that other 9p21 genes may be involved in melanoma/nevi development. To identify 9p21 variants that influence susceptibility to CMM and number of nevi in CMM-prone families with and without CDKN2A mutations, we analyzed...
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