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Article

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.

PloS one - 1 Jan 2012

Machado Diana, Couto Isabel, Perdigão João, Rodrigues Liliana, Portugal Isabel, Baptista Pedro, Veigas Bruno, Amaral Leonard, Viveiros Miguel

Abstract excerpt

Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. Here, we investigated the mechanism by which resistance towards isoniazid develops and how overexpression of efflux pumps favors accumulation of mutations in isoniazid targets, thus establishing a MDR phenotype. The study was based on the...

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Identifiers

PMID: 22493700
DOI: 10.1371/journal.pone.0034538
PMCID: PMC3321020

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