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Article

Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2009

Kono Dwight H, Haraldsson M Katarina, Lawson Brian R, Pollard K Michael, Koh Yi Ting, Du Xin, Arnold Carrie N, Baccala Roberto, Silverman Gregg J, Beutler Bruce A, Theofilopoulos Argyrios N

Abstract excerpt

Using the Unc93b1 3d mutation that selectively abolishes nucleic acid-binding Toll-like receptor (TLR) (TLR3, -7, -9) signaling, we show these endosomal TLRs are required for optimal production of IgG autoAbs, IgM rheumatoid factor, and other clinical parameters of disease in 2 lupus strains, B6-...

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Share to Antibodies, Antinuclear
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred MRL lpr

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Source

Open in PubMed Open full text

Identifiers

PMID: 19574451
DOI: 10.1073/pnas.0905441106
PMCID: PMC2715524

Genes

TLR3
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19574451-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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