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Article

High diversity of the immune repertoire in humanized NOD.SCID.γc<sup>−/−</sup> mice

1 Jul 2009

Abstract excerpt

The diversity of the human immune repertoire and how it relates to a functional immune response has not yet been studied in detail in humanized NOD.SCID.gammac(-/-) immunodeficient mice. Here, we used a multiplex PCR on genomic DNA to quantify the combinatorial diversity of all possible V-J rearrangements at the TCR-beta chain and heavy chain Ig locus. We first show that the combinatorial diversity of the...

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PMID: 19572320
DOI: 10.1002/eji.200939480

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