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Article

Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families.

Breast cancer research and treatment - 1 Feb 2010

Solyom Szilvia, Patterson-Fortin Jeffery, Pylkäs Katri, Greenberg Roger A, Winqvist Robert

Abstract excerpt

MERIT40 is a recently identified BRCA1 and RAP80 interacting protein that is essential for protein-protein interactions of a BRCA1 complex also containing Abraxas, BRCC36 and BRCC45. It is a mediator of checkpoint functions and DNA damage signaling through a (de)ubiquitination cascade. Based on its interaction with BRCA1 and its role in genome integrity maintenance, MERIT40 is a novel candidate gene for being...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19572197
DOI: 10.1007/s10549-009-0453-7
PMCID: PMC2863093

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families.PMID 19572197Read ↗

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Structural and functional characterization of the MERIT40 to understand its role in DNA repair.Semantic proximity Read ↗

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.Semantic proximity Read ↗

Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.Semantic proximity Read ↗

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