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Article

Germline RAP80 mutations and susceptibility to breast cancer.

Breast cancer research and treatment - 1 Jan 2009

Akbari Mohammad Reza, Ghadirian Parviz, Robidoux Andre, Foumani Maryam, Sun Yulong, Royer Robert, Zandvakili Inuk, Lynch Henry, Narod Steven A

Abstract excerpt

Most of the breast cancer susceptibility genes identified to date are involved in DNA repair, including BRCA1, BRCA2, PALB2, CHEK2 and BRIP1. RAP80 works upstream of BRCA1 and is essential for the localization of BRCA1 to the site of damaged DNA. To investigate whether or not RAP80 is also a breast cancer susceptibility gene, we sequenced the entire exonic regions of RAP80 in the germline DNA of 152 women with...

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Source

Identifiers

PMID: 18306035
DOI: 10.1007/s10549-008-9938-z

Genes

BRCA1
BRCA2
BRIP1
CHEK2
PALB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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