Article
Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes.
Cancer research - 1 Sept 2011
Rebbeck Timothy R, Mitra Nandita, Domchek Susan M, Wan Fei, Friebel Tara M, Tran Teo V, Singer Christian F, Tea Muy-Kheng Maria, Blum Joanne L, Tung Nadine, Olopade Olufunmilayo I, Weitzel Jeffrey N, Lynch Henry T, Snyder Carrie L, Garber Judy E, Antoniou Antonis C, Peock Susan, Evans D Gareth, Paterson Joan, Kennedy M John, Donaldson Alan, Dorkins Huw, Easton Douglas F, Rubinstein Wendy S, Daly Mary B, Isaacs Claudine, Nevanlinna Heli, Couch Fergus J, Andrulis Irene L, Freidman Eitan, Laitman Yael, Ganz Patricia A, Tomlinson Gail E, Neuhausen Susan L, Narod Steven A, Phelan Catherine M, Greenberg Roger, Nathanson Katherine L
Abstract excerpt
Inherited BRCA1 mutations confer elevated cancer risk. Recent studies have identified genes that encode proteins that interact with BRCA1 as modifiers of BRCA1-associated breast cancer. We evaluated a comprehensive set of genes that encode most known BRCA1 interactors to evaluate the role of these genes as modifiers of cancer risk. A cohort of 2,825 BRCA1 mutation carriers was used to evaluate the association of...
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