Article
Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.
Oncogene - 23 Apr 2009
Nikkilä J, Coleman K A, Morrissey D, Pylkäs K, Erkko H, Messick T E, Karppinen S-M, Amelina A, Winqvist R, Greenberg R A
Abstract excerpt
Germline mutations in two major susceptibility genes, BRCA1 and BRCA2, account for nearly 20% of familial breast cancers. A majority of the remaining genetic factors involved in heritable breast cancer susceptibility are, however, unknown. Recently, a new BRCA1-interacting protein, receptor associated protein 80 (RAP80), was identified. RAP80 plays an important role in BRCA1-mediated DNA damage responses (DDRs)...
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