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Article

Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function.

Biology of reproduction - 1 Nov 2009

Morrow Carla M K, Tyagi Gaurav, Simon Liz, Carnes Kay, Murphy Kenneth M, Cooke Paul S, Hofmann Marie-Claude C, Hess Rex A

Abstract excerpt

The blood-testis barrier (BTB) is formed by tight junctions between Sertoli cells. Results of previous studies suggested that the barrier is deficient in ets variant 5 (ETV5) gene-deleted mice; therefore, microarray data were examined for changes in tight junction-associated genes. The tight junctional protein claudin 5 (CLDN5) was decreased in testes of 8-day-old Etv5(-/-) pups. The study reported herein...

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Source

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Identifiers

PMID: 19571261
DOI: 10.1095/biolreprod.109.077040
PMCID: PMC2770019

Genes

CLDN5
ETV5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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