Article
Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease
24 Mar 2022
Abstract excerpt
Although mature podocytes lack tight junctions, tight junction integral membrane protein claudin-5 (CLDN5) is predominantly expressed on plasma membranes of podocytes under normal conditions. Using podocyte-specific Cldn5 knockout mice, we identify CLDN5 as a crucial regulator of podocyte function and reveal that Cldn5 deletion exacerbates podocyte injury and proteinuria in a diabetic nephropathy mouse model....
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