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Article

Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 2009

Lee Jin-A, Gao Fen-Biao

Abstract excerpt

Autophagy is a conserved lysosomal protein degradation pathway whose precise roles in age-dependent neurodegenerative diseases remain largely unknown. Here we show that the autophagy inhibitor 3-methyladenine delays neuronal cell loss caused by dysfunctional endosomal sorting complex required for transport III (ESCRT-III), either through loss of its essential component mSnf7-2 or ectopic expression of the disease...

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Source

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Identifiers

PMID: 19571141
DOI: 10.1523/JNEUROSCI.0924-09.2009
PMCID: PMC2726650

Genes

CHMP2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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